Calhoun County is a county located in the U.S. state of South Carolina. A 2005 Census Bureau estimate placed the population at 15,100. Its county seat is St. Matthews.
History
It is named for John C. Calhoun, the former U.S. Vice-President, Senator, Representative and cabinet member from South Carolina. It was formed in 1908 from portions of Lexington and Orangeburg counties.